(This is a continuation of the notes I have taken from the Sabah Lymphoma talk ) I. Lymphadenopathies Lymphadenopathies are divided into three: 1. Reactive lymphoid hyperplasia 2. Atypical lymphoid hyperplasia 3. Progressive transformation of germinal centre 1. Reactive lymphoid hyperplasia Has a follicular pattern OR may present as diffuse paracortical hyperplasia. Characteristics: architecture preserved, capsule intact, enlarged germinal centre, mitotically active, tingible body macrophages, mantle zone present . Main differential of follicular pattern: follicular lymphoma. 2. Progressive transformation of germinal centre Mainly in adolescent males. Numerous follicules in different stages with follicular hyperplasia. Late stage: small lymphocytes infiltrating germinal centres, germinal centre disrupted. II. Castleman's disease 1. Hyaline vascular variant Can be unilocular or multiple places. Numerous follicles with small germinal centre, on...
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