The Histopathologoid

O'Brien M J ,  Zhao Q ,  Yang S  ( 2015 )  Histopathology   66 ,  49 – 65 . DOI:  10.1111/his.12564 Colorectal serrated pathway cancers and precursors Again had another read of a free review article in Histopathology regarding colorectal serrated lesions, because lo and behold I have a diagnostic dilemma between hyperplastic polyp and sessile serrated polyp. To be continued.

Mention the term 'serrated lesions" (of the colorectum) and immediately I will get a brief panic attack.  Based on my limited knowledge, the lesions sound and look the same.  Even when a senior teacher made a nice diagram of how to differentiate all of these lesions, it still did not hit me how things work... until today. There is a nice review article in Journal of Clinical Pathology regarding pathological diagnosis of serrated lesions by Bateman and Shepherd ( J Clin Pathol   2015 ; 68 : 585 - 591).   I think it very helpful in terms of clearing up the terminologies involved. Basically, the recommended terminology of serrated lesions in the colorectum is as follows: 1. Hyperplastic polyp 2.  Sessile serrated lesion (SSL) 3.  SSL with dysplasia 4. Traditional serrated adenoma 5. Mixed polyp Hyperplastic polyp is easy enough, but what about sessile serrated lesions?  They have listed the key histological features as follows: ...