Giant cell tumour of bone (vs aneurysmal cyst)

In giant cell tumour of bone, what we will see is:
1. Multiple numerous nuclei within cell with ill-defined border (in other words, multinucleated cell)
usually more than 10 nuclei; usually 50-100 nuclei
2. Mixture of multinucleated cells with neoplastic mononuclear cells
3. Mitosis rarely seen, with no atypical forms seen.

Whereas for aneurysmal bone cyst (a potential differential diagnosis), what we will see is:
Lumen containing blood surrounded by bone and collagen.

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8 L's and DRUGS

I am so happy that I found an educational gem by Sullivan Nicolaides Pathology , a private pathology lab in Australia. There are some videos of live lectures that one can find here. I am particularly excited (and maybe starstruck) to find Professor David Weedon's lectures here -- as I am particularly fond for Dermatopathology. A particular thing I learned today from Professor David Weedon was a checklist mnemonic for perivascular infiltrate in the skin: 8L's and DRUGS Light reaction Lymphoma (and pseudo) Leprosy Lues Lichen striatus Lupus erythematosus Lipoidica (and incomplete granuloma annulare) Lepidoptera (arthropods etc) Dermatophyte Reticular erthymatous mucinosis Urticaria Gyrate erythema Scleroderma

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The Histopathologoid

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