Giant cell tumour of bone (vs aneurysmal cyst)

In giant cell tumour of bone, what we will see is:
1. Multiple numerous nuclei within cell with ill-defined border (in other words, multinucleated cell)
usually more than 10 nuclei; usually 50-100 nuclei
2. Mixture of multinucleated cells with neoplastic mononuclear cells
3. Mitosis rarely seen, with no atypical forms seen.

Whereas for aneurysmal bone cyst (a potential differential diagnosis), what we will see is:
Lumen containing blood surrounded by bone and collagen.

Comments

8 L's and DRUGS

I am so happy that I found an educational gem by Sullivan Nicolaides Pathology , a private pathology lab in Australia. There are some videos of live lectures that one can find here. I am particularly excited (and maybe starstruck) to find Professor David Weedon's lectures here -- as I am particularly fond for Dermatopathology. A particular thing I learned today from Professor David Weedon was a checklist mnemonic for perivascular infiltrate in the skin: 8L's and DRUGS Light reaction Lymphoma (and pseudo) Leprosy Lues Lichen striatus Lupus erythematosus Lipoidica (and incomplete granuloma annulare) Lepidoptera (arthropods etc) Dermatophyte Reticular erthymatous mucinosis Urticaria Gyrate erythema Scleroderma

How to gross a Whipple's specimen

Just mentioning presence of a Whipple's specimen in the lab would bring throngs of histopathology trainees to observe the grossing of the specimen. It is associated with intimidating combination of organs, many margins to remember, and last but definitely not least, the lament of a trainee saying: "Where is the tumour??" When I was a second year Pathology Masters student (first year Histopathology trainee), a senior trainee taught us a simplified way to gross a Whipple's specimen. It is the same as any other textbook, but the lack of wordiness (as compared to the textbook) make it less intimidating. (Picture from www.pancreapedia.org) 1. Margins Stomach (proximal margin) Duodenum (distal margin) Uncinate (Soft tissue margin) Anterior pancreas Common...

Reactive Conditions of the Lymph Node

(This is a continuation of the notes I have taken from the Sabah Lymphoma talk ) I. Lymphadenopathies Lymphadenopathies are divided into three: 1. Reactive lymphoid hyperplasia 2. Atypical lymphoid hyperplasia 3. Progressive transformation of germinal centre 1. Reactive lymphoid hyperplasia Has a follicular pattern OR may present as diffuse paracortical hyperplasia. Characteristics: architecture preserved, capsule intact, enlarged germinal centre, mitotically active, tingible body macrophages, mantle zone present . Main differential of follicular pattern: follicular lymphoma. 2. Progressive transformation of germinal centre Mainly in adolescent males. Numerous follicules in different stages with follicular hyperplasia. Late stage: small lymphocytes infiltrating germinal centres, germinal centre disrupted. II. Castleman's disease 1. Hyaline vascular variant Can be unilocular or multiple places. Numerous follicles with small germinal centre, on...

The Histopathologoid

Search This Blog